Masteron aka Drostanolone Propionate is a dihydrotestosterone (DHT) derived anabolic steroid. Actually, Masteron is the DHT hormone that has been structurally modified by the inclusion of a methyl group at the carbon 2 position as reflected by its chemical name 2 alpha-Methyl-4,5-dihydrotestosterone propionate. This alteration protects the hormone from metabolic elimination by the 3-hydroxysteroid dehydrogenase enzyme, which is present in the skeletal muscle tissue. This change also significantly enhances the hormone’s anabolic nature where normally it would not have the ability to do so. This basic structural modification is what it takes to create Drostanolone, and the addition of a short Propionate ester is required in order to control the hormone’s release time.
Masteron/Drostanolone was first officially created and introduced in 1959 by Syntex Pharmaceuticals. Syntex was a preferred brand in the pharmaceutical industry in regards to the creation of several anabolic steroids which are recognized and used today. Some of their more popular anabolic steroids are Superdrol (Methyldrostanolone) and Anadrol (Oxymetholone). That’s right, Syntex was responsible for one of the most popular and strongest oral steroid of all time. Let’s have a moment of silence in recognition of the greatness of Anadrol.
Despite the fact that Masteron was officially created in 1959, it didn’t reach the prescription drug market until 10 years later under the trade and brand name known as Masteron. Thanks to a collaborative agreement Lilly Pharmaceuticals would market Drostanolone in the United States under the name Drolban and Syntex would handle the marketing of Masteron internationally. Masteron is not medically used for putting on muscle as with most steroids, thus making it a unique steroid from that point of view. The majority of information on Masteron focuses on its use in treating certain forms of breast cancer, which it does fairly well. Most of the information on Masteron available in medical journals and studies do not focus on weight or strength gain or even fat loss, for those reasons.
Masteron’s clinical use was determined to be mainly for the treatment of female breast cancer, often as one of the last resort treatment options after other solutions have failed. It was used and developed under the generic name Masteril for its treatment purposes. Because Masteron has a much lower androgenic rating than Testosterone, it would be more suitable for female use because of the lower chance of virilization to occur. Very few other anabolic steroids had been produced with low androgenic ratings that would work in the treatment of breast cancer in female patients, typically a group that does not tend to react well to anabolic steroid treatments because of the inherent risk of virilization due to androgenic effects.
In combination with other compounds such as Tamoxifen, it in fact preformed better than chemotherapy regarding immediate responses from patients. Masteron has been discontinued for use but remains an approved drug by in the U.S by the FDA. There are two varieties of Masteron that are typically available for use – Drostanolone Propionate and Drostanolone Enanthate. The propionate version has a half life of 1-2 days and is commonly dosed at 50-150mg/ml. It is the faster acting type requiring injection every other day to maintain proper levels. The enanthate variety of Masteron, in most cases, is only found on the black market from underground labs. It has a half life of 5-6 days and is usually dosed at 200mg/ml. The addition of longer lasting enanthate ester provides a slower release of the hormone meaning an injection is only needed 1-2 times per week depending on desired result. Common dosing for black market Masteron Enathate is 20mg/ml every 7 days.